Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification

聚集誘導發光（Aggregation-induced emission, AIE）探針由于其極高的靈敏度和極佳的光穩定性在癌癥診斷和治療等方面具有不可估量的應用前景。線粒體作為所有細胞共有的重要細胞器,在癌細胞和正常細胞中顯示出明顯的性質區別,因此可作為線粒體靶向AIE探針區分癌細胞與正常細胞的靶標。本文介紹了線粒體靶向AIE探針的設計方法、成像機理以及它們對癌細胞與正常細胞、循環腫瘤細胞與白細胞以及癌細胞和相關細菌與正常細胞的區別成像。這些熒光探針在癌癥診斷、手術導航、癌癥治療的效果評估和后續復發監測以及細胞污染評估等方面具有廣闊的應用前景。通過本文的介紹,能夠讓更多讀者了解AIE探針在癌細胞識別方面的顯著優勢,激發開發性能更為豐富的探針材料和開展更為深入的研究,從而促進生物醫學領域的快速發展,造福人類。 Aggregation-induced emission(AIE) probes have shown great potential in cancer diagnosis and therapy due to their excellent sensitivity and photo-stability. Mitochondria, which is regarded as one of the most important organelles in cells, has obvious difference between cancer cells and normal cells. Thus, it is reliable to utilize mitochondria-targeted AIE probes to distinguish cancer from normal cells. In this review, we exhibit the design principle and imaging mechanism of AIE probes for mitochondria target, and their distinguishing imaging between cancer cells and normal cells, circulating tumor cells and leukocyte, and dual identification imaging of cancer cells and related bacteria. The probes show remarkable advantages in cancer diagnosis, surgical navigation, cancer treatment assessment and recurrence monitoring, and cell pollution evaluation. We hope, this review will motivate to develop more AIE probes with rich properties and conduct deeper researches to promote the rapid development of biomedical field and maintain human health. © 2021, Science Press. All right reserved.