Reader response: WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis — In Memory of Vinod Kumar Gupta (2020) | RDL Network
I read with interest the article on white matter hyperintensities (WMH) by Georgakis et al.1 suggesting that WMH are linked to long-term outcomes in ischemic stroke. Pathogenesis of WMH is uncertain, and generalization is difficult.2 WMH are also found bilaterally in migraine patients, with no definitive long-term deterioration in functional or cognitive abilities despite the continuation of age-related accelerated atherosclerosis.2,3
Marios K. Georgakis, Rainer Malik, Harry Björkbacka, Tiberiu A. Pana, Serkalem Demissie, Colby Ayers, Mohamed A. Elhadad, Myriam Fornage, Alexa S. Beiser, Emelia Benjamin, S. Matthijs Boekholdt, Gunnar Engström, Christian Herder, Ron C. Hoogeveen, Wolfgang Köenig, Olle Melander, Marju Orho‐Melander, Alexandru Șchiopu, Martin Söderholm, Nicholas J. Wareham, Christie M. Ballantyne, Annette Peters, Sudha Seshadri, Phyo Kyaw Myint, Jan Nilsson, James A. de Lemos, Martin Dichgans
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