Reader response: Body composition status and the risk of migraine: A meta-analysis

I read with interest the article by Gelaye et al.1 regarding influence of body mass index (BMI), at both ends of the spectrum, on incidence of migraine. Meta-analyses are susceptible to all intrinsic biases of all observational studies and have spurred a quest for statistical truth that risks drawing clinicians away from clinical reality or common sense.2,3 In addition, there is no requirement for a generalized robust overarching theoretical matrix to conduct a meta-analysis, pooling—as they do—data from several studies that frequently do not ask the same research question.