Purine Derivatives of 1,2-Disubstituted Cyclohexane Analogues of Nucleosides

Carmen Terán; Lourdes Santana; Eugenio Uriarte; Dolores Viña; De Clercq Erik

doi:10.1081/ncn-120022635

Abstract

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Starting from (+/-)-cis-2-hydroxymethylcyclohexylamine, a series of cyclohexane-derived cis-1,2-disubstituted carbonucleoside analogues with a 6- or 2,6-purine or 8-azapurine base were synthesized. The antiviral and antitumoral in vitro effects of the new compounds were evaluated.

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