Stereoselective Synthesis ofNovel Aristeromycin Analogues as Potential Antiviral Agents

Gérard Audran; Paul Brémond; Honoré Monti; De Clercq Erik

doi:10.1055/s-0028-1083146

Abstract

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A series of 3′-methyl-branched and purine-modified analogues of aristeromycin were synthesized via the SN2 displacement of a key triflate, which was prepared from a readily available enantiopure building block in eight steps. The synthesized compounds were evaluated as potential antiviral agents against important viruses. Only the 2,6-diaminopurine derivative exhibited moderate activity against vesicular stomatitis virus.

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