The brain has a high oxygen consumption and is rich in oxidizable substrates, mainly catecholamines and unsaturated lipids. Much interest has been shown recently in ‘oxygen radicals’ as mediators of the action of certain neurotoxins, in the role of vitamin E in the nervous system and in the possible use of anti-oxidants in treating degenerative diseases of the nervous system and the consequences of ischaemia. The purpose of this brief review is to explain some of the scientific background to these developments.
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