DNA and Free Radicals

Oxidants are major contributors to cancer and aging. Part 1 Chemistry and measurement of damage to DNA by reactive oxygen species: chemistry of free radical damage to DNA and nucleoproteins DNA damage induced by photosensitization oxidative damage - meaning and measurement. Part 2 Mechanism of DNA damage by oxidative stress: hydrogen peroxide and DNA damage oxidative stress and calcium homeostasis lipid peroxidation and cancer the role of organic peroxyl radicals carcinogenesis. Part 3 Consequences of oxidative DNA damage: enzymes that repair oxidative damage to DNA sex as a response to oxidative DNA damage oxidative stress and cell proliferation in vitro ornithine decarboxylase and tumour promotion - a role for oxidants. Part 4 Pro-oxidants and DNA damage: redox cycling drugs and DNA damage role of reactive oxygen species the mutagenicity of complex mixtures of plant origin mineral fibres, cigarette smoke and oxidative DNA damage use of DNA damage as a measure of pro-oxidant actions of antioxidant food additives and nutrient components.