ORIGINAL RESEARCH The Topography of Brain Microstructural Damage in Amyotrophic Lateral Sclerosis Assessed Using Diffusion Tensor MR Imaging — Elisa Canu (2011) | RDL Network
ORIGINAL RESEARCH The Topography of Brain Microstructural Damage in Amyotrophic Lateral Sclerosis Assessed Using Diffusion Tensor MR Imaging
Article 2011 en
Authors
EC
Elisa Canu
FA
Federica Agosta
NR
Nilo Riva
Abstract
1 min read
ALS leads to macrostructural (ie, cortical atrophy and hyperintensitiesalong the corticospinal tract) and microstructural (ie, gray matter intrinsic damage) central nervoussystem abnormalities. We used a multimodal voxelwise imaging approach to assess microstructuralchanges independent of macrostructural volume loss in patients with ALS compared with HCs.
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