There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.
Augusto Villanueva, Clara Alsinet, Kilangsungla Yanger, Yujin Hoshida, Yiwei Zong, Sara Toffanin, Leonardo Rodríguez‐Carunchio, Manel Solé, Swan N. Thung, Ben Z. Stanger, Josep M. Llovet
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