Myasthenia Gravis, Thrombocytopenia and HLA Antigens

Letters and Corrections1 August 1977Myasthenia Gravis, Thrombocytopenia and HLA AntigensGIUSEPPE REMUZZI, M.D., MANUELA LIVIO, M.D., MARIA BENEDETTA DONATI, M.D., PH.D., GIOVANNI DE GAETANO, M.D., PH.D.GIUSEPPE REMUZZI, M.D.Search for more papers by this author, MANUELA LIVIO, M.D.Search for more papers by this author, MARIA BENEDETTA DONATI, M.D., PH.D.Search for more papers by this author, GIOVANNI DE GAETANO, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-250_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Segal and Weintraub (1) have reported a patient with Hashimoto's thyroiditis, myasthenia gravis, and autoimmune thrombocytopenic purpura. They suggested that the association of these three autoimmune disorders in the same patient might be due to a single pathogenetic mechanism and concluded that a defect in immunologic response could make a selected population more liable to develop certain autoimmune disorders.We have recently seen a patient with myasthenia gravis and autoimmune thrombocytopenia and have discussed the possibility that the same genetic marker might be involved in the predisposition to both disorders (2).The patient is a 29-year-old woman...References1. SEGALWEINTRAUB BM: Hashimoto's thyroiditis, myasthenia gravis, idiopathic thrombocytopenic purpura. Ann Intern Med 85:761-763, 1976 LinkGoogle Scholar2. REMUZZIMISIANILIVIO GRM: Possible role of HLA-B8 antigen as a genetic marker of autoimmune thrombocytopenia in a patient with myasthenia gravis, submitted to Br J Haematol Google Scholar3. HIRSCHMANSHULMAN RN: The use of platelet serotonin release as a sensitive method for detecting anti-platelet antibodies and a plasma antiplatelet factor in patients with idiopathic thrombocytopenic purpura. Br J Haematol 24:793-802, 1973 CrossrefMedlineGoogle Scholar4. FRITZEHERRMANNAEIM DCF: HL-A antigens in myasthenia gravis. Lancet 1:240-243, 1974 CrossrefMedlineGoogle Scholar5. GOEBELHAHNHAVEMANN KEK: HLA matching in autoimmune thrombocytopenic purpura. Br J Haematol 35:341-342, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nephrology and Dialysis Division Ospedali Riuniti Bergamo Italy Mario Negri Institute for Pharmacological Research Milan Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFamilial association of autoimmune thrombocytopenia and hyperthyroidismEffect of thymectomy on myasthenia gravis and autoimmune thrombocytopenic purpura in a 13-year-old girlEffect of Thymectomy on Myasthenia Gravis and Autoimmune Thrombocytopenic Purpura in a 13-Year-Old GirlNeurologyEndocrinologyHyperthyroidism and immune thrombocytopenia.Autoantibodies to Platelet Glycoprotein IIb/IIIa and to the Acetylcholine Receptor in a Patient with Chronic Idiopathic Thrombocytopenic Purpura and Myasthenia GravisMICHAEL J. ANDERSON, M.D., VIRGIL L. WOODS Jr., M.D., PATRICIA TANI, B.A., JON M. LINDSTROM, Ph.D., DONALD SCHMIDT, M.D., ROBERT McMILLAN, M.D.Genetic factors predisposing to autoimmune diseasesMyasthenia Gravis and Werlhof's Disease 1 August 1977Volume 87, Issue 2Page: 250-251KeywordsAntigensGenetic diseasesGenetic predispositionHuman leukocyte antigenIdiopathic thrombocytopenic purpuraMyasthenia gravisPathogensThyroid Issue Published: 1 August 1977 PDF downloadLoading ...