Limited Polymorphism in the Dihydropteroate Synthetase Gene ( <i>dhps</i> ) of <i>Plasmodium vivax</i> Isolates from Thailand
Antimicrobial Agents and Chemotherapy 49(10): 4393-4395
Article 2005 English
Authors
MI
Mallika Imwong
SP
Sasithon Pukrittayakamee
QC
Qin Cheng
Abstract
1 min read
The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A --> G) in 33 isolates, all from Thailand. Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.
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