Gene Amplification of the Multidrug Resistance 1 Gene of <i>Plasmodium vivax</i> Isolates from Thailand, Laos, and Myanmar — Mallika Imwong (2008) | RDL Network
Gene Amplification of the Multidrug Resistance 1 Gene of <i>Plasmodium vivax</i> Isolates from Thailand, Laos, and Myanmar
Antimicrobial Agents and Chemotherapy 52(7): 2657-2659
Article 2008 English
Authors
MI
Mallika Imwong
SP
Sasithon Pukrittayakamee
WP
Wirichada Pongtavornpinyo
Abstract
1 min read
Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.
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