Influence of Polyol/Salt Additives on the Drug-Mediated Phase Separation and Thermodynamic Properties of Triton X-100

Herein, we investigated the impact of different additives [polyols (glucose, galactose, and maltose)/electrolytes (KCl, K2SO4, and K3PO4·7H2O)] on the interaction between quinolone antibiotic drug, ciprofloxacin hydrochloride (CFH), and Triton X-100 (TX-100) via the cloud point (CP) measurement technique. The magnitudes of CP of TX-100 were observed to be reduced with the enlargement of TX-100 concentration. The CP values show U-shaped variation as a function of CFH concentration in the aqueous medium. The CP values dwindle in the existence of electrolyte, which continues with the rise of electrolyte concentration. The observed CP values in the electrolyte medium follow the order CPK3PO4·7H2O > CPK2SO4 > CPKCl. The CP values reduced in the presence of organic additives (polyols) also. The executed magnitudes of Gibbs free energy (ΔGc°) of clouding were positive in all cases, signifying the nonspontaneous phenomenon. The ΔGc° values reduce with TX-100 concentration. The values of enthalpy of clouding (ΔHc°) and entropy of clouding (ΔSc°), as well as different transfer properties of thermodynamic parameters, were estimated and interpreted in detail. Excellent entropy–enthalpy compensation was observed in all cases.