In memory of an exquisite medicinal chemist, Prof. Morris Robins

Among the most prominent realizations of Morris J. Robins in the antiviral nucleoside chemistry are <i>(i)</i> the synthesis of 8-substituted (methyl-, amino-, bromo-, iodo) derivatives of acyclovir, <i>(ii)</i> xylotubercidin as an inhibitor of herpes simplex virus (HSV) infections, <i>(iii)</i> the anti-HIV activity of the 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and the 3'-azido- and 3'-fluoro derivatives thereof (AzddDAPR and FddDAPR, respectively), <i>(iv)</i> the potentiating effect of ribavirin on the anti-HIV activity of 2',3'-dideoxyinosine (ddI) and ddDAPR, <i>(v)</i> S-adenosylhomocysteine hydrolase (SAH) inhibitors principally active against vaccinia virus (VV) and vesicular stomatitis virus (VSV), and <i>(vi)</i> furo[2,3-d]pyrimidinone derivatives active against varicella-zoster virus (VZV).