The Unabated Synthesis of New Nucleoside Analogues with Antiviral Potential: A Tribute to Morris J. Robins

De Clercq Erik

doi:10.1080/15257770903054159

Abstract

1 min read

The furo[2,3-d]pyrimidin-2(3H)-one is the key structural determinant in the exquisitely potent activity of its derivatives (R = 2-deoxyribosyl; R' = p-pentylphenyl) against VZV (varicella-zoster virus) replication. [structure: see text].

Discussion(0)

No comments yet. Be the first to comment.

Related publications

Article2005

Synthesis and Biological Evaluation of Acyclic 3-[(2-Hydroxyethoxy)methyl] Analogues of Antiviral Furo- and Pyrrolo[2,3-d]pyrimidine Nucleosides

Zlatko Janeba, Jan Balzarini, Graciela Andreï, Robert Snoeck, De Clercq Erik, Morris J. Robins

Article2005

Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives

Morris J. Robins, Karl Miranda, Vivek K. Rajwanshi, Matt A. Peterson, Graciela Andreï, Robert Snoeck, De Clercq Erik, Jan Balzarini

Article2007

Synthesis and Antiviral Evaluation of 6-(Alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one Nucleosides and Analogues with Ethynyl, Ethenyl, and Ethyl Spacers at C6 of the Furopyrimidine Core

Morris J. Robins, Ireneusz Nowak, Vivek K. Rajwanshi, Karl Miranda, John F. Cannon, Matt A. Peterson, Graciela Andreï, Robert Snoeck, De Clercq Erik, Jan Balzarini

Article2024

In memory of an exquisite medicinal chemist, Prof. Morris Robins

De Clercq Erik

Article2006

Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives

Zlatko Janeba, Jan Balzarini, Graciela Andreï, Robert Snoeck, De Clercq Erik, Morris J. Robins

The Unabated Synthesis of New Nucleoside Analogues with Antiviral Potential: A Tribute to Morris J. Robins

Abstract

Discussion(0)

Related publications

Synthesis and Biological Evaluation of Acyclic 3-[(2-Hydroxyethoxy)methyl] Analogues of Antiviral Furo- and Pyrrolo[2,3-<i>d</i>]pyrimidine Nucleosides

Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3<i>-d</i>]pyrimidin-2(3<i>H</i>)-one Base and Nucleoside Derivatives

Synthesis and Antiviral Evaluation of 6-(Alkyl-heteroaryl)furo[2,3-<i>d</i>]pyrimidin-2(3<i>H</i>)-one Nucleosides and Analogues with Ethynyl, Ethenyl, and Ethyl Spacers at C6 of the Furopyrimidine Core

In memory of an exquisite medicinal chemist, Prof. Morris Robins

Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(<i>p</i>-toluenesulfonyl)uracil derivatives