Importance of Collection Tube during Clinical Studies of Oseltamivir
Antimicrobial Agents and Chemotherapy 51(5): 1835-1836
Article 2007 English
Authors
NL
Niklas Lindegårdh
GD
Geraint Davies
TH
Tran Tinh Hien
Abstract
1 min read
Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step: incubation at 60°C for 45 min.
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