Rapid Degradation of Oseltamivir Phosphate in Clinical Samples by Plasma Esterases
Antimicrobial Agents and Chemotherapy 50(9): 3197-3199
Article 2006 English
Authors
NL
Niklas Lindegårdh
GD
Geraint Davies
TH
Tran Tinh Hien
Abstract
1 min read
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.
Niklas Lindegårdh, Warunee Hanpithakpong, Benjamas Kamanikom, Pratap Singhasivanon, Duong Socheat, Poravuth Yi, Arjen M. Dondorp, Rose McGready, François Nosten, Sir Nicholas White, Nicholas Day
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