Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells — OA Gressner (2009) | RDL Network
Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells
Article 2009 en
Authors
OG
OA Gressner
BL
Birgit Lahme
KR
Katharina Rehbein
Abstract
1 min read
Aims: Recently, we identified hepatocytes as the major cellular source of profibrogenic connective tissue growth factor (CTGF/CCN2) in the liver. Based on reports of a hepatoprotective effect of coffee consumption, we were the first to give evidence that caffeine suppresses TGF-β dependent and -independent CTGF expression in hepatocytes, thus suggesting this xanthine-alkaloid as a potentially therapeutic agent.
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