Identification of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

Da Feng; Xiaofang Zuo; Fabao Zhao; Hao Lin; Jiaojiao Dai; Yangyin Sun; De Clercq Erik; Christophe Pannecouque; Dongwei Kang; Xinyong Liu; Peng Zhan

doi:10.1016/j.ejmech.2022.115045

Back

Identification of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

Article 2022 en

Related publications

Article2020

Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

Da Feng, Xiaofang Zuo, Lanlan Jing, Chin‐Ho Chen, Fisayo A. Olotu, Hao Lin, Mahmoud E. S. Soliman, De Clercq Erik, Christophe Pannecouque, Kuo‐Hsiung Lee, Dongwei Kang, Xinyong Liu, Peng Zhan

Article2018

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site

Dongwei Kang, Zhongxia Zhou, Gaochan Wu, Samuel Desta, Xiaofang Zuo, Zhao Wang, Lanlan Jing, Xiao Ding, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Zhipeng Huo, Heng Zhang

Preprint2025

Design, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles

Xiangkai Ji, Xiangyi Jiang, X. T. Huang, Heng Gao, Zhen Gao, Ping Gao, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu

Article2025

Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles

Xiangkai Ji, Xiangyi Jiang, X. T. Huang, Heng Gao, Zhen Gao, Ping Gao, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu

Article1991

Site-directed mutagenesis of HIV-1 reverse transcriptase

K De Vreese, Zeger Debyser, Rudi Pauwels, De Clercq Erik, Jan Desmyter, Jozef Anné

Identification of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

Discussion(0)

Related publications

Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the “NNRTI Adjacent” Binding Site

Design, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles

Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles

Site-directed mutagenesis of HIV-1 reverse transcriptase