Cyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP) — A New Prodrug Approach for FdUMP

Martina Lorey; Chris Meier; De Clercq Erik; Jan Balzarini

doi:10.1080/07328319708006177

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Cyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP) — A New Prodrug Approach for FdUMP

Article 1997 en

Abstract

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Abstract The synthesis of cycloSal-FdUMP 3a-d as a new prodrug approach for FdU 1 is described. Phosphotriesters 3 release the FdUMP 2 selectively by a controlled, chemically induced tandem reaction in hydrolysis studies. The biological activity (IC50) of cycloSal-phosphotriesters 3 was evaluated in FM3A/O cells and FM3A/TK− cells.

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<i>Cyclo</i>-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (<i>cyclo</i>Sal-FdUMP) — A New Prodrug Approach for FdUMP

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New Synthesis and Antitumor Activity of <i>Cyclo</i>Sal- Derivatives of 5-Fluoro-2′-deoxyuridinemonophosphate

<i>Cyclo</i>-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (<i>cyclo</i>Sal-d4TMP) — A New Pro-Nucleotide Approach

<i>Cyclo</i>-Saligenyl-3′-Azido-2′,3′-Dideoxy- Thymidinemonophosphate (<i>cyclo</i>Sal-AZTMP) - A New Pro-Nucleotide Approach<sup>1</sup> ?-

<i>cyclo</i>Sal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (<i>cyclo</i>Sal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System

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