Cyclo-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (cycloSal-d4TMP) — A New Pro-Nucleotide Approach

Chris Meier; Martina Lorey; De Clercq Erik; Jan Balzarini

doi:10.1080/07328319708006176

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Cyclo-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (cycloSal-d4TMP) — A New Pro-Nucleotide Approach

Article 1997 he

Abstract

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Abstract The synthesis of cycloSal-d4TMP 3a-g as new pro-nucleotide approach for d4TMP 2 is described. Phosphotriesters 3 release the d4TMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited high biological activity against HIV-1/HIV-2 in CEM cells which was completely retained in CEM TK− cells.

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<i>Cyclo</i>-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (<i>cyclo</i>Sal-d4TMP) — A New Pro-Nucleotide Approach

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<i>Cyclo</i>-Saligenyl-3′-Azido-2′,3′-Dideoxy- Thymidinemonophosphate (<i>cyclo</i>Sal-AZTMP) - A New Pro-Nucleotide Approach<sup>1</sup> ?-

<i>cyclo</i>Sal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (<i>cyclo</i>Sal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System

<i>Cyclo</i>-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (<i>cyclo</i>Sal-FdUMP) — A New Prodrug Approach for FdUMP

New Synthesis and Antitumor Activity of <i>Cyclo</i>Sal- Derivatives of 5-Fluoro-2′-deoxyuridinemonophosphate

<i>cyclo</i>Sal-Pronucleotides of 2‘,3‘-Dideoxyadenosine and 2‘,3‘-Dideoxy-2‘,3‘-didehydroadenosine: Synthesis and Antiviral Evaluation of a Highly Efficient Nucleotide Delivery System