Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Monique M.A. Verstegen; Floris J.M. Roos; Ksenia Burka; Helmuth Gehart; Myrthe Jager; Maaike de Wolf; Marcel J. C. Bijvelds; Hugo R de Jonge; Arif I. Ardisasmita; Nick A. van Huizen; Henk P. Roest; Jeroen de Jonge; Michael Koch; Francesco Pampaloni; Sabine A. Fuchs; Imre F. Schene; Theo M. Luider; Hubert P.J. van der Doef; Frank A J A Bodewes; Ruben H. J. de Kleine; Bart Spee; Gert-Jan Kremers; Hans Clevers; Jan N.M. IJzermans; Edwin Cuppen; Luc J. W. van der Laan; Monique M.A. Verstegen; Floris J.M. Roos; Ksenia Burka; Helmuth Gehart; Myrthe Jager; Maaike de Wolf; Marcel J. C. Bijvelds; Hugo R de Jonge; Arif I. Ardisasmita; Nick A. van Huizen; Henk P. Roest; Jeroen de Jonge; Michael Koch; Francesco Pampaloni; Sabine A. Fuchs; Imre F. Schene; Theo M. Luider; Hubert P.J. van der Doef; Frank A J A Bodewes; Ruben H. J. de Kleine; Bart Spee; Gert-Jan Kremers; Hans Clevers; Jan N.M. IJzermans; Edwin Cuppen; Luc J. W. van der Laan

doi:10.1038/s41598-020-79082-8

Related publications

Article2023

Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease

Fjodor A. Yousef Yengej, Carla Pou Casellas, Carola M. E. Ammerlaan, Charlotte J.A. Olde Hanhof, Emre Dilmen, Joep Beumer, Harry Begthel, Elise M. G. Meeder, Joost G.J. Hoenderop, Maarten B Rookmaaker, Marianne C. Verhaar, Hans Clevers

Article2019

Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

Karin M. de Winter – de Groot, Gitte Berkers, Rozemarijn E.P. Marck – van der Wilt, Renske van der Meer, Annelotte M. Vonk, Johanna F. Dekkers, Margot Geerdink, Sabine Michel, Evelien Kruisselbrink, Rob B.M. de Vries, Hans Clevers, Frank P. Vleggaar, Sjoerd G. Elias, Harry Heijerman, Cornelis K. van der Ent, Jeffrey M. Beekman

Article2018

Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease

Luigi Maiuri, Guido Guido Kroemer

Preprint2019

Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma

Elisa De Crignis, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Monique M.A. Verstegen, Mir M. Khalid, Farzin Pourfarzad, Shringar Rao, Ameneh Bazrafshan, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles A. Boucher, Jan M.N. IJzermans, Meritxell Huch, Sylvia F. Boj, Robert G.J. Vries, Hans Clevers, Luc J. W. van der Laan, Pantelis Hatzis, Tokameh Mahmoudi

Article2021

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Shringar Rao, Ameneh Bazrafshan, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan Nm IJzermans, Meritxell Huch, Sylvia F. Boj, Robert Vries, Hans Clevers, Luc Jw van der Laan, Pantelis Hatzis, Tokameh Mahmoudi