Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

Karin M. de Winter – de Groot; Gitte Berkers; Rozemarijn E.P. Marck – van der Wilt; Renske van der Meer; Annelotte M. Vonk; Johanna F. Dekkers; Margot Geerdink; Sabine Michel; Evelien Kruisselbrink; Rob B.M. de Vries; Hans Clevers; Frank P. Vleggaar; Sjoerd G. Elias; Harry Heijerman; Cornelis K. van der Ent; Jeffrey M. Beekman

doi:10.1016/j.jcf.2019.10.022

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Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

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24 Stratification for cystic fibrosis (CF) disease severity in adults with CF with homozygous F508del mutations by intestinal organoids

Forskolin-induced Swelling in Intestinal Organoids: An &lt;em&gt;In Vitro&lt;/em&gt; Assay for Assessing Drug Response in Cystic Fibrosis Patients

Forskolin-induced Swelling in Intestinal Organoids: An &lt;em&gt;In Vitro&lt;/em&gt; Assay for Assessing Drug Response in Cystic Fibrosis Patients

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function

WS04-5 The TOPAZ study, a large-scale study in organoids derived from F508del homozygous cystic fibrosis patients treated with Orkambi

Forskolin-induced Swelling in Intestinal Organoids: An <em>In Vitro</em> Assay for Assessing Drug Response in Cystic Fibrosis Patients

Forskolin-induced Swelling in Intestinal Organoids: An <em>In Vitro</em> Assay for Assessing Drug Response in Cystic Fibrosis Patients