High-dose Administration of Levofloxacin (LVFX) in the Treatment of Acute Exacerbation of Chronic Otitis Media.

Thirty-two adult cases of acute exacerbation of chronic otitis media (COM) were treated by high-dose (600mg/day) oral administration of levofloxacin (LVFX). Clinically, 27COM cases (84.4%) were effectively treated, and no apparent side effects were noted during this study protocol. Among 31 clinically isolated strains whose therapeutic outcomes were bacteriologically confirmed, 28 (90%) strains were not detectable after high-dose LVFX treatment. Bacteriological therapeutic failures in the treatment were observed in three COM patients with MRSA and a patient with coagulase-negative staphylococci. High-dose administration of LVFX was effective in the treatment of acute exacerbation of COM except in cases that were caused by drug resistant staphylococci.