Gold(I)-Catalyzed Enantioselective Intramolecular Hydroamination of Allenes

Rebecca Lyn LaLonde; Benjamin D. Sherry; Eun Joo Kang; Dean Toste

doi:10.1021/ja068819l

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Gold(I)-Catalyzed Enantioselective Intramolecular Hydroamination of Allenes

Article 2007 en

Abstract

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The asymmetric intramolecular hydroamination of allenes catalyzed by phosphinegold(I)−bis-p-nitrobenzoate complexes is described. This reaction is applicable to the enantioselective formation of vinyl pyrrolidines and piperidines in 70−99% ee.

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