Gold-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation

Metal-catalyzed enantioselective intramolecular hydroamination or hydroalkoxy­lation is one of the most effective and atom-­economical methods to construct enantioenriched heterocycles. This paper presents complementary methods for the efficient synthesis of chiral vinyl isoxolidines, tetrahydrooxazines, and pyrazolidines by gold(I)-catalyzed intramolecular addition of hydrazines and hydroxylamines to allenes.