Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder
Article 2014 en
Authors
CK
Christian Kubisch
LQ
Lydia Quaye
FW
Frances M. K. Williams
Abstract
1 min read
Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine.We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS).We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97 × 10(-8), OR: 1.82, 95% CI: 1.47-2.25), although this was not replicated in a smaller sample of 289 migraine cases.Our study is based on self-reported migraine.NBEA encodes neurobeachin, a scaffolding protein primarily expressed in the brain and involved in trafficking of vesicles containing neurotransmitter receptors. This locus has not previously been implicated in migraine per se. We found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder.
Verneri Anttila, Bendik S. Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George Davey Smith, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela M. Terwindt, Sarah E. Medland, Unda Todt, Wendy L. McArdle, George Davey Smith, Markku Koiranen, M. Arfan Ikram, Terho Lehtimäki, Lannie Ligthart, Juho Wedenoja, Ian Dunham, Benjamin M. Neale, Priit Palta, Eija Hämäläinen, Markus Schuerks, Roberto Jorge da Silva Franco, Julie E. Buring, Paul M. Ridker, Stacy Steinberg, Hreinn Stefánsson, Finnbogi Jakobsson, Debbie A. Lawlor, Susan M. Ring, Martti Färkkilâ, Ville Artto, Mari Kaunisto, Tobias Freilinger, Jean Schoenen, Nadine Pelzer, Claudia M Weller, Ronald Zielman, Pamela A. F. Madden, Grant W. Montgomery, Nicholas G. Martin, Guntram Borck, Hartmut Goebel, Katja Heinze‐Kuhn, Frances M. K. Williams, Anneli Pouta, Joyce van den Ende, André G. Uitterlinden, Albert Hofman, Najaf Amin, Jouke‐Jan Hottenga, Jacqueline M. Vink, Kauko Heikkilä, Michael P. Alexander, Bertram Müller−Myhsok, Stefan Schreiber, Thomas Meitinger, Arpo Aromaa, Johan G. Eriksson, Bryan J. Traynor, Daniah Trabzuni, Elizabeth J. Rossin, Kasper Lage, Suzanne B.R. Jacobs, J. Raphael Gibbs, Ewan Birney, Jaakko Kaprio, Brenda W.J.H. Penninx, Dorret I. Boomsma, Cornelia M. van Duijn, Olli T. Raitakari, Paul M Ridker, John‐Anker Zwart, David P. Strachan, Christian Kubisch, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Martin Dichgans, Maija Wessman, George Davey Smith, Kāri Stefánsson, Aarno Palotie, Dale R. Nyholt, Daniel I. Chasman, Aarno Palotie
Heidi Hautakangas, Bendik S. Winsvold, Sanni Ruotsalainen, Gyða Björnsdóttir, Aster V. E. Harder, Lisette J. A. Kogelman, Laurent F. Thomas, Raymond Noordam, Christian Benner, Padhraig Gormley, Ville Artto, Karina Banasik, Anna Bjornsdottir, Dorret I. Boomsma, Ben Brumpton, Kristoffer Sølvsten Burgdorf, Julie E. Buring, Mona Ameri Chalmer, Irene de Boer, Martin Dichgans, Christian Erikstrup, Martti Färkkilâ, Maiken Elvestad Garbrielsen, ,
Discussion(0)
No comments yet. Be the first to comment.