Genome-wide meta-analysis identifies new susceptibility loci for migraine
Article 2013 en
Authors
VA
Verneri Anttila
BW
Bendik S. Winsvold
PG
Padhraig Gormley
Abstract
1 min read
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
Grant W. Montgomery, Eija Hämäläinen, Hui‐Chun Huang, Andrea Byrnes, Lude Franke, Jia Huang, Evie Stergiakouli, P.H. Lee, Cynthia Sandor, Caleb Webber, M. Zameel Cader, Bertram Müller−Myhsok, Stefanie Schreiber, Thomas Meitinger, Johan G. Eriksson, Veikko Salomaa, Katri Heikkilä, Elizabeth Loehrer, André G. Uitterlinden, Albert Hofman, Cornelia M. van Duijn, Lynn Cherkas, Linda M. Pedersen, Audun Stubhaug, Christopher Sivert Nielsen, Minna Männikkö, Evelin Mihailov, Lili Milani, Hartmut Göbel, Ann-Louise Esserlind, A. F. Christensen, Thomas Hansen, Thomas Werge, Jaakko Kaprio, Arpo Aromaa, Olli Raitakari, Ikram, T. D. Spector, Paul M Ridker, Andres Metspalu, Christian Kubisch, D P Strachan, Ferrari, Andrea Carmine Belin, Martin Dichgans, Maija Wessman, Arn M. J. M. van den Maagdenberg, John‐Anker Zwart, D.I. Boomsma, George Davey Smith, Hreinn Stefánsson, Nicholas Eriksson, Mark J. Daly, Benjamin M. Neale, Jes Olesen, Padhraig Gormley, Verneri Anttila, Bendik S. Winsvold, Priit Palta, Tõnu Esko, Tune H. Pers, Kai-How Farh, Ester Cuenca-León, Mikko Muona, Nick Furlotte, Tobias Kurth, Andrés Ingason, George McMahon, Lannie Ligthart, G.M. Terwindt, Mikko Kallela, Tobias Freilinger, Caroline Ran, Gillian M Gordon, A. H. Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H.H. Adams, Terho Lehtimäki, Antti-Pekka Sarin, Juho Wedenoja, David A. Hinds, JE Buring, Markus Schürks, Paul M. Ridker, Maria Gudlaug Hrafnsdottir, Hreinn Stefánsson, Susan M. Ring, J-J Hottenga, Brenda W.J.H. Penninx, Martti Färkkilâ, Ville Artto, M. Kaunisto, Saila Vepsäläinen, Rainer Malik, Andrew C. Heath, P.A. Madden, Gabriela Martín
Padhraig Gormley, Verneri Anttila, Bendik S. Winsvold, Priit Palta, Tõnu Esko, Tune H. Pers, Kai-How Farh, Ester Cuenca-León, Mikko Muona, Nicholas A. Furlotte, Tobias Kurth, Andrés Ingason, George McMahon, Lannie Ligthart, Gisela M. Terwindt, Mikko Kallela, Tobias Freilinger, Caroline Ran, Scott D. Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H.H. Adams,
Heidi Hautakangas, Bendik S. Winsvold, Sanni Ruotsalainen, Gyða Björnsdóttir, Aster V. E. Harder, Lisette J. A. Kogelman, Laurent F. Thomas, Raymond Noordam, Christian Benner, Padhraig Gormley, Ville Artto, Karina Banasik, Anna Bjornsdottir, Dorret I. Boomsma, Ben Brumpton, Kristoffer Sølvsten Burgdorf, Julie E. Buring, Mona Ameri Chalmer, Irene de Boer, Martin Dichgans, Christian Erikstrup, Martti Färkkilâ, Maiken Elvestad Garbrielsen, ,
Heidi Hautakangas, Bendik S. Winsvold, Sanni Ruotsalainen, Gyða Björnsdóttir, Aster V. E. Harder, Lisette J. A. Kogelman, Laurent F. Thomas, Raymond Noordam, Christian Benner, Padhraig Gormley, Ville Artto, Karina Banasik, Anna Bjornsdottir, Dorret I. Boomsma, Ben Brumpton, Kristoffer Sølvsten Burgdorf, Julie E. Buring, Mona Ameri Chalmer, Irene de Boer, Martin Dichgans, Christian Erikstrup, Martti Färkkilâ, Maiken Elvestad Garbrielsen, ,
Else Eising, Sjoerd M. H. Huisman, Ahmed Mahfouz, Lisanne S. Vijfhuizen, Verneri Anttila, Bendik S. Winsvold, Tobias Kurth, M. Arfan Ikram, Tobias Freilinger, Jaakko Kaprio, Dorret I. Boomsma, Cornelia M. van Duijn, Paul M Ridker, John‐Anker Zwart, Lydia Quaye, David P. Strachan, Christian Kubisch, Martin Dichgans, George Davey Smith, Kāri Stefánsson, Aarno Palotie, ,
Discussion(0)
No comments yet. Be the first to comment.