GC-MS rapid screening of eight non-steroidal anti-inflammatory drugs in health foods and traditional Chinese medicines

Objective:To establish a GC-MS method for detection of non-steroidal anti-inflammatory drugs that illegally added in health foods and traditional Chinese medicines.Method:Samples were extracted and enriched by using solvent extraction or liquid-liquid extraction method.Qualitative detection was carried out by GC-MS and Scan mode.In addition,quantitative analysis was performed using Selected ion monitoring(SIM) mode.The analytical capillary column was DP-5 ms(30 m×0.25 mm×0.25 μm).The oven temperature was set at 120 ℃(1 min) initially,it was programmed to rise to 230 ℃ at 10 ℃·min-1,and then rise to 270 ℃ at 15 ℃·min-1 20 min).The EI ion source was selected and the solvent was delayed by 2.5 min.The MS scanning was set at the range of 40-350 amu.Result:Under the selected chromatographic conditions,8 kinds of chemical drugs could get a better separation within 30 min.4-acetamidophenol and diclofenac sodium were detected in two batches of samples.Conclusion:This method is rapid,accurate,and selective,which is suitable for fast qualitative detection of drugs added illegally.