FIGURE 6 from Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy

<p>Impact of AZA treatment on mutant cell populations in responder patients. <b>A,</b> Mutant cell type proportions at diagnosis and after AZA treatment in responders. *, scCODA FDR <0.1. <b>B,</b> UMAPs at diagnosis and after AZA in all the HMA responder patients, colored by number of mutations per cell, highlight the three mutant populations significantly associated with response. <b>C,</b> UMAPs highlighting mutant HSPCs in patient #2 (responder), mutant immature granulocytes in patient #9 (responder) and mutant immature monocytes in patient #7 (responder), colored by clone. Dx, diagnosis; Aza, after AZA treatment.</p>