FIGURE 3 from Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy

<p>Clonal evolution of responder and nonresponder patients with MDS upon AZA treatment. <b>A,</b> Clonal phylogenies of patients #3 and #14 (responders) and #4 and #8 (nonresponders) at diagnosis. Dot size represents clone size. <b>B,</b> Fishplots of patients #3 and #14 (responders) and #4 and #8 (nonresponders), illustrating the clonal distribution at diagnosis and after AZA treatment. <b>C,</b> Proportion of mutant cells (left) and predominant mutant clone (right) in responder patients at diagnosis and after AZA treatment. Dx, diagnosis; Aza, after AZA treatment.</p>