FIGURE 4 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

<p>Immunoregulatory interactions shape the immunosuppressive microenvironment of Ewing sarcoma. <b>A,</b> Number of unique interactions between tumor cells and indicated main cell types. <b>B,</b> Bubble plot of predicted immunosuppressive interactions between indicated myeloid subsets and tumor cells. For full overview see <a href="#SMF9" target="_blank">Supplementary Fig. S9A</a>. <b>C,</b> Dotplot of genes included in the selected, predicted interactions, shown in B, and expressed by the main cell types and per-patient tumor cells. <b>D,</b> Number of unique interactions between T/NK cells and indicated main cell types. <b>E,</b> Bubble plot of predicted interactions between indicated myeloid subsets and CD8<sup>+</sup> T cells and are correlating (>0.5) with CD8<sup>+</sup> T-cell dysfunction score. <b>F,</b> Dotplot of genes included in T cell dysfunction–promoting interactions, highlighted in orange in E, and expressed by the myeloid cells.</p>