FIGURE 2 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

<p>Ewing sarcoma–associated lymphocytes display variable degrees of dysfunctionality and immune suppression. <b>A,</b> UMAP and dotplot of the T- and NK-cell subsets and a selection of their marker genes. <b>B,</b> Heat map showing average expression of inhibitory receptors in the T- and NK-cell subsets. *Significantly upregulated with <i>P</i> < 0.0001 using Wilcoxon rank-sum test with Bonferroni correction. <b>C,</b> Dysfunction scores constructed using genes from B. Cell types ordered from high to low score. *, <i>P</i> < 0.05; ***, <i>P</i> < 0.001 versus Naïve T.</p>