FIGURE 1 from Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy

<p>Mutational landscape of patients with the studied MDS. <b>A,</b> Summary of the study workflow. <b>B,</b> Oncoprint indicating the mutations present in the patient cohort, at diagnosis and after AZA treatment, colored by coding impact. Multi-hit means presence of more than one mutation of same coding impact (missense, nonsense, or frameshift) in the same gene. <b>C,</b> UpSet plot illustrating the exclusive intersection of mutated pathways at diagnosis in patients with MDS. The patients are colored according to the response status (green, responders; magenta, nonresponders). </p>