Evidence for Interaction between<i>PPARG</i>Pro12Ala and<i>PPARGC1A</i>Gly482Ser Polymorphisms in Determining Type 2 Diabetes Intermediate Phenotypes in Overweight Subjects
Experimental and Clinical Endocrinology & Diabetes 117(09): 455-459
Article 2009 English
Authors
SR
Stéphanie-May Ruchat
SW
S. John Weisnagel
MV
Marie‐Claude Vohl
Abstract
1 min read
Background: The peroxisome proliferator-activated receptor-γ (PPARG) Pro12Ala and the PPARG co-activator-1α (PPARGC1A) Gly482Ser polymorphisms (SNPs) have been associated with type 2 diabetes mellitus (T2DM) risk. We hypothesized that independent and interactive effects of the PPARG Pro12Ala and PPARGC1A Gly482Ser polymorphisms influence T2DM intermediate phenotypes.
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