Enantioselective Halocyclization Using Reagents Tailored for Chiral Anion Phase-Transfer Catalysis

Yiming Wang; Jeffrey C.S. Wu; Christina Hoong; Vivek Rauniyar; Dean Toste

doi:10.1021/ja305795x

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Enantioselective Halocyclization Using Reagents Tailored for Chiral Anion Phase-Transfer Catalysis

Article 2012 en

Abstract

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A chiral anion phase-transfer system for enantioselective halogenation is described. Highly insoluble, ionic reagents were developed as electrophilic bromine and iodine sources, and application of this system to o-anilidostyrenes afforded halogenated 4H-3,1-benzoxazines with excellent yield and enantioselectivity.

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