Enantioselective Fluoroamination: 1,4‐Addition to Conjugated Dienes Using Anionic Phase‐Transfer Catalysis

Hunter P. Shunatona; Natalja Früh; Yiming Wang; Vivek Rauniyar; Dean Toste

doi:10.1002/anie.201302002

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Enantioselective Fluoroamination: 1,4‐Addition to Conjugated Dienes Using Anionic Phase‐Transfer Catalysis

Article 2013 en

Abstract

1 min read

Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.

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