Detection of adenine-rich ssDNA based on thymine-substituted tetraphenylethene with aggregation-induced emission characteristics — Xiaoding Lou (2014) | RDL Network
Detection of adenine-rich ssDNA based on thymine-substituted tetraphenylethene with aggregation-induced emission characteristics
Article 2014 en
Authors
XL
Xiaoding Lou
CL
Chris Wai Tung Leung
CD
Chao Dong
Abstract
1 min read
In this work, tetraphenylethene (TPE) equipped with thymine, TPE–T, was synthesized and used as a fluorescence biosensor for differentiating ssDNA from dsDNA. TPE–T is a “turn-on” fluorescence probe once it forms hydrogen bonds with single-stranded adenine-containing oligonucleotides with high sensitivity and specificity. The working mechanism of TPE–T and its potential in cell imaging are investigated in detail.
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