Design and development of curcumin bioconjugates as antiviral agents

Dinesh Rai; Desh Deepak Yadav; Jan Balzarini; De Clercq Erik; Rekha Singh

doi:10.1093/nass/nrn303

Abstract

1 min read

A number of curcumin bioconjugates with fatty acid, dipeptide and folic acid, viz. di-O-decanoyl curcumin (2), di-O-tryptophanylphenylalanine curcumin (3), di-O-bis-(gamma, gamma)folyl curcumin (4), C(4)-ehyl-O-gamma-folyl curcumin (5) and 4-O-ethyl-O-gamma-folyl curcumin (6) have been synthesized. Conjugates 2-6 have shown good antiviral property with EC(50) ranging between 0.019-0.105 microM against a wide range of viruses, like HIV, HSV, VSV and many others.

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