Chemoenzymatic Syntheses of Homo‐ and Heterodimers of AZT and d4T, and Evaluation of Their Anti‐HIV Activity
Article 2004 en
Authors
MT
Moha Taourirte
LM
L. Ait Mohamed
AR
A. Rochdi
Abstract
1 min read
Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
Moha Taourirte, L. Ait Mohamed, A. Rochdi, Jean‐Jacques Vasseur, Susana Fernández, Miguel Ferrero, Vicente Gotor, Christophe Pannecouque, De Clercq Erik, Hassan B. Lazrek
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