Causal relationships between migraine and microstructural white matter: a Mendelian randomization study

Lei Zhao; Wenhui Zhao; Verneri Anttila; Ville Artto; Andrea Carmine Belin; Anna Bjornsdottir; Gyða Björnsdóttir; Dorret I. Boomsma; Sigrid Børte; Mona Ameri Chalmer; Daniel I. Chasman; Bru Cormand; Ester Cuenca-León; George Davey Smith; Irene de Boer; Martin Dichgans; Tõnu Esko; Tobias Freilinger; Padhraig Gormley; Lyn R. Griffiths; Eija Hämäläinen; Thomas Hansen; Aster V. E. Harder; Heidi Hautakangas; Marjo Hiekkala; Maria Gudlaug Hrafnsdottir; M. Arfan Ikram; Paul M Ridker; Risto Kajanne; Mikko Kallela; Jaakko Kaprio; Mari Kaunisto; Lisette J. A. Kogelman; Espen Saxhaug Kristoffersen; Christian Kubisch; Mitja Kurki; Tobias Kurth; Lenore J. Launer; Terho Lehtimäki; Davor Lessel; Lannie Ligthart; Sigurður H. Magnússon; Rainer Malik; Bertram Müller−Myhsok; Carrie A. M. Northover; Dale R. Nyholt; Jes Olesen; Aarno Palotie; Priit Palta; Linda M. Pedersen; Nancy L. Pedersen; Matti Pirinen; Daniëlle Posthuma; Patricia Pozo‐Rosich; Alice Pressman; Olli Raitakari; Caroline Ran; Gudrun R. Sigurdardottir; Hreinn Stefánsson; Kāri Stefánsson; Ólafur Sveinsson; Gisela M. Terwindt; Thorgeir E. Thorgeirsson; Arn M. J. M. van den Maagdenberg; Cornelia M. van Duijn; Maija Wessman; Bendik S. Winsvold; John‐Anker Zwart; Jin Cao; Yiheng Tu

doi:10.1186/s10194-023-01550-z

Abstract

1 min read

Migraine is a disabling neurological disorder with the pathophysiology yet to be understood. The microstructural alteration in brain white matter (WM) has been suggested to be related to migraine in recent studies, but these evidence are observational essentially and cannot infer a causal relationship. The present study aims to reveal the causal relationship between migraine and microstructural WM using genetic data and Mendelian randomization (MR).

Related publications

Article2025

Exploring potential causal relationships between gut microbiota, inflammatory factors, and postpartum depression: a Mendelian randomization analysis

Hui Li, Hongyan Meng, Chunxiao Dang, Pengfei Liu, Jinxing Liu, Xiao Yu, Zhong Lin Wang, Lilv, Xiaohui Sui

Preprint2021

White matter disruption as a cause or consequence of schizophrenia: A Mendelian randomization study

Oskar Hougaard Jefsen, Maria Speed, Karl Friston, Søren Dinesen Østergaard, Doug Speed

Preprint2024

The role of mitochondrial DNA copy number in neuropsychiatric disorders: A bidirectional two-sample Mendelian randomization study

Mengqi Niu, Chen Chen, Michael Maes

Preprint2020

Coffee consumption and risk of breast cancer: a Mendelian Randomization study

Merete Ellingjord‐Dale, Nikos Papadimitriou, Michail Katsoulis, Chew Yee, Niki Dimou, Dipender Gill, Dagfinn Aune, Jue‐Sheng Ong, Stuart MacGregor, Benjamin Elsworth, Sarah Lewis, Richard M. Martin, Elio Riboli, Konstantinos K. Tsilidis

Article2013

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

Karani S. Vimaleswaran, Diane J. Berry, Lu Chen, Emmi Tikkanen, Stefan Pilz, Linda T. Hiraki, Jason D. Cooper, Zari Dastani, Rui Li, Denise K. Houston, Andrew R. Wood, Karl Michaëlsson, Liesbeth Vandenput, Lina Zgaga, Laura M. Yerges-Armstrong, Mark I. McCarthy, Josée Dupuis, Marika Kaakinen, Marcus E. Kleber, Anthony James, Nigel Arden, Olli Raitakari, Jorma Viikari, Kurt K. Lohman,