Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response — Lei Zhu (2022) | RDL Network
Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Communications Biology 5(1)
Article 2022 English
Authors
LZ
Lei Zhu
RP
Rob W. van der Pluijm
MK
Michal Kucharski
Abstract
1 min read
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Nosten, Abul Faiz, Chanak Amaratunga, Dysoley Lek, Elizabeth A. Ashley, Frank Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, Mehul Dhorda, Nguyen Hoang Chau, Thuy-Nhien Nguyen, Paul N. Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J. Peto, Olivo Miotto, Lorenz von Seidlein, Tran Tinh Hien, Hagai Ginsburg, Nicholas Day, Sir Nicholas White, Arjen M. Dondorp, Zbynek Bozdech
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