The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response. — Lei Zhu (2021) | RDL Network
The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.
Preprint 2021 English
Authors
LZ
Lei Zhu
RP
Rob W. van der Pluijm
MK
Michal Kucharski
Abstract
1 min read
The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodeling and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, Frank Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, Mehul Dhorda, Nguyen Hoang Chau, Thuy-Nhien Nguyen, Paul N. Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J. Peto, Olivo Miotto, Lorenz von Seidlein, Tran Tinh Hien, Hagai Ginsburg, Nicholas Day, Sir Nicholas White, Arjen M. Dondorp, Zbynek Bozdech
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, Sir Nicholas White, Nicholas Day, Abul Faiz, Aung Pyae Phyo, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, François Nosten, Frank Smithuis, Hagai Ginsburg, Lorenz von Seidlein, Khin Lin, Mallika Imwong, Kesinee Chotivanich, Mayfong Mayxay, Mehul Dhorda, Hoang Chau Nguyen, Thuy-Nhien Nguyen,
Sachel Mok, Elizabeth A. Ashley, Pedro Eduardo Ferreira, Lei Zhu, Zhaoting Lin, Tomas Yeo, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Mehul Dhorda, Chea Nguon, Pharath Lim, Chanaki Amaratunga, Seila Suon, Tran Tinh Hien, Ye Htut, Mohammad Abul Faiz, Marie Onyamboko, Mayfong Mayxay, Paul N. Newton, Rupam Tripura, Charles J. Woodrow, Olivo Miotto, Dominic Kwiatkowski,
Lei Zhu, Jaishree Tripathi, Frances Rocamora, Olivo Miotto, R. van der Pluijm, Till S. Voss, Sachel Mok, Dominic Kwiatkowski, François Nosten, Nicholas Day, Sir Nicholas White, Arjen M. Dondorp, Zbynek Bozdech, Aung Pyae Phyo, Elizabeth A. Ashley, Frank Smithuis, Khin Lin, Kyaw Myo Tun, M Abul Faiz, Mayfong Mayxay, Mehul Dhorda, Thuy-Nhien Nguyen, Paul N. Newton, Sasithon Pukrittayakamee,
Mallika Imwong, Kanokon Suwannasin, Chanon Kunasol, Kreepol Sutawong, Mayfong Mayxay, Rekol Huy, Frank Smithuis, Tin Maung Hlaing, Kyaw Myo Tun, Rob W. van der Pluijm, Rupam Tripura, Olivo Miotto, Didier Ménard, Mehul Dhorda, Nicholas Day, Sir Nicholas White, Arjen M. Dondorp
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