Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma — Jong Kook Park (2009) | RDL Network
Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma
Article 2009 en
Authors
JP
Jong Kook Park
EL
Eun Joo Lee
CE
Christine Esau
Abstract
1 min read
We demonstrate that antisense to miR-21 and miR-221 results in significant cell killing under various conditions and that antisense oligonucleotides targeted to miRNA represents a potential new therapy for pancreatic cancer.
Eun Joo Lee, Yuriy Gusev, Jinmai Jiang, Gerard J. Nuovo, Megan R. Lerner, Wendy L. Frankel, Daniel L. Morgan, Russell G. Postier, Daniel J. Brackett, Thomas D Schmittgen
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