It is always of critical importance to scrutinize biomedical studies for accuracy, especially those even suggesting benefits of novel applications for widely used medications. An example is a 2018 retrospective Taiwanese study in which Tzeng claims that patients with HSV infections ‘may have’ a 2.56-fold increased risk of developing dementia. Furthermore, and more appropriate to the title of his paper (<em>Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections-a Nationwide, Population-Based Cohort Study in Taiwan</em>), Tzeng claimed that the usage of anti-herpetic medications was associated with a decreased risk of dementia. However imperfections in the study suggest the need for a more controlled study. For example, in the HSV-group merely 13.7% (1147 in 8362) did not receive anti-herpetic medications [1].
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