Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock*

Xinrong He; Fuhong Su; Dimitrios Velissaris; Diamantino Salgado; Dalton de Souza Barros; Sophie Lorent; Fabio Silvio Taccone; Jean Louis Vincent; Daniel De Backer

doi:10.1097/ccm.0b013e31825b88ba

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Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock*

Article 2012 en

Abstract

1 min read

In this clinically relevant model of sepsis, tetrahydrobiopterin supplementation attenuated the impairment in sublingual microvascular perfusion and permeability, which was accompanied by better preserved gas exchange, renal flow and urine output, and prolonged survival.

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