(A) LMP1/CD40 mice showed a splenomegaly with a 3

5-fold increase of the splenic weight compared with control mice with B cells carrying the stop cassette (LMP1/CD40). Representative spleens from 8-wk-old LMP1/CD40 and control mice are shown. (B) Absolute numbers of B220 B cells and CD3 T cells in spleen (SP) of LMP1/CD40 and control mice. The horizontal bars mark the mean. (C) Spleen sections from LMP1/CD40 and control mice were stained for B cells (red, anti-IgM) and T cells (top; blue, anti-CD3), or for B cells (red, anti-IgM) and metallophilic macrophages (blue, anti-MOMA1), which are localized at the border between follicular (FO) and marginal zone (MZ) B cells (bottom). Arrowheads indicate marginal zone B cells. Bars, 400 μm. (D) Absolute numbers of B220 B cells in inguinal LN and BM of LMP1/CD40 and control mice. The horizontal bars mark the mean.<b>Copyright information:</b>Taken from "Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis"The Journal of Experimental Medicine 2008;205(6):1317-1329.Published online 9 Jun 2008PMCID:PMC2413030.