A CYCLOBUTANE CARBONUCLEOSIDE WITH MARKED SELECTIVITY AGAINST TK+AND TK−VARICELLA ZOSTER VIRUS

Carmen López; Carmen Balo; JoséM. Blanco; F. FERNÁNDEZ; De Clercq Erik; Jan Balzarini

doi:10.1081/ncn-100002505

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A CYCLOBUTANE CARBONUCLEOSIDE WITH MARKED SELECTIVITY AGAINST TK+AND TK−VARICELLA ZOSTER VIRUS

Article 2001 en

Abstract

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Several cyclobutyladenine and analogous carbonucleosides were synthesized from 1R-alpha-pinene and their anti-viral activity was tested. One of them (3e) showed interesting selectivity against both TK+ and TK- VZV.

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A CYCLOBUTANE CARBONUCLEOSIDE WITH MARKED SELECTIVITY AGAINST TK<sup>+</sup>AND TK<sup>−</sup>VARICELLA ZOSTER VIRUS