1H-MRS neurometabolite profiles and motor development in school-aged children who are HIV-exposed uninfected: a birth cohort study

Simone R. Williams; Frances Robertson; Catherine J. Wedderburn; Jessica E. Ringshaw; Layla Bradford; Charmaine N. Nyakonda; Nadia Hoffman; Shantanu H. Joshi; Heather J. Zar; Dan Joseph Stein; Kirsten A. Donald

doi:10.3389/fnins.2023.1251575

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1H-MRS neurometabolite profiles and motor development in school-aged children who are HIV-exposed uninfected: a birth cohort study

Article 2023 en

Abstract

1 min read

Reduced Glu concentrations in the parietal gray matter may suggest regional alterations in excitatory glutamatergic transmission pathways in the context of perinatal HIV and/or antiretroviral therapy (ART) exposure, while reduced Cho ratios in the parietal white matter suggest regional myelin loss. Identified associations between neurometabolite profiles and gross and fine motor developmental outcomes in CHEU are suggestive of a neurometabolic mechanism that may underlie impaired motor neurodevelopmental outcomes observed in CHEU.

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