13PHD1 deficiency promotes an atheroprotective metabolic phenotype
Article 2014 en
Authors
EM
Elke Marsch
JD
Jasper A. F. Demandt
TT
Thomas Theelen
Abstract
1 min read
Knockout of the oxygen-sensor HIF prolyl hydroxylase 1 (PHD1) was shown to switch metabolism towards glycolysis and reduced cellular oxygen consumption. As we recently showed a pro-atherosclerotic effect of plaque hypoxia, we hypothesised that reduced cellular oxygen consumption in PHD1 knockout mice alleviates atherosclerosis development.
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